Unfortunately, this is the first time we've heard about the game not starting at all on Windows 10. Are you sure it's not an antivirus program blocking the game?
I only have Windows defender and any other game from Itch runs fine. If it's a renpy game it should have the same permissions as any other game. I tried running it as an admin and still didn't work
Not opening at all definetly seems Like either faulty download or something blocking the .exe. I‘m not sure what else could do this honestly. It‘s a normal renpy game.
