Very nice. It took a couple of tries to get my muscle memory back but then I got two bosses at floor 1 and snowballed from there.
The new purchasable buffs are a godsend, the shield saved me on floor 2 from being chain frozen to death and on floor 3 from having dodged into 3 newly spawned mines. I think you should lean less on passive damage resistances and more on the ones that modify the alchemist's moves and abilities if you want the player to feel like they're choosing a build, right now it's mostly flat buffs without much synergy or strategy, but as a first implementation and for what is the first third of a full run I think you've aced it.
The ethereal dodge one is really fun, it's great to be able to put obstacles between you and the constructs.
Going by the description alone the one that gives you a chance to absorb enemy elements seems like something I would either fail to notice when it happens or not be in a position to use that specific element effectively.
I still think mines are a bit too oppressive in the smaller rooms but since they're rare in the first two floor and the shop upgrades give you a nice safety net it's not as bad as before.
The merchant lady's audio was very bass boosted and distorted, idk if it's just too loud or it simply didn't agree with my headphones.
After changing the resolution the arsenal was the only one that didn't rescale properly until I restarted.
Very nice overall! Will play more of this.