Sorry for the late response, I’m graduating today and had to check with my co-host lol
If the bus drive has the experiences of a road trip, it should be ok. E.g: stopping for meals and gas, staying at hotels, sightseeing, etc. I think the difference between a road trip and a regular bus travel in your case would be more important.
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They don’t have to know each other from the get-go. Getting to know (or hate) strangers during the trip is ok.
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The interactions don’t have to be positive. If you want everyone in the vehicle to hate each other’s guts/ actively plan for their murders/not care about each other, that’s okay. The social aspect can be as negative as you want, not all road trips are fun times for everyone.
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Minibus and van are ok, my own game has a van as it vehicle.