First thought - that button animation is absolutely beautiful lol holy crap.
I appreciate the inverted aiming, it's a clever way to prevent you from using your cursor trivializing aiming.
I think the camera controls might be a little unnecessary and add unneeded complexity. I think it'd be ideal if the room just fit on one fixed screen.
Controlling the drone shots feels a touch beyond comprehension. I agree with Rakudajin that it probably needs something to assist with understanding where your shots will end up. It could be a limited aimline, or maybe it's reducing the possible angles for a drone shot. If the turrets clicked into place into, say, 16 possible angles instead of being totally free form, it could give the player a starting point for making adjustments each attempt. It becomes hard to iterate when the slightest change in shot angle results in a widely different outcomes.
Overall, well done! I think this is a really cool game. I also really like the music, it really fits the game.