Tested the web build, so I can not say anything about the Wwise integration.
Theme is implemented and part of the game loop which is nice.
I like the VFX and also in animations in general. The walk animation looks a bit odd as it does not really match the movement speed, or so it seems.
Audio seems nice too.
Could not figure out what the differend runes do, but it does not matter too much as it seems, the push back of the 2nd boss when it fires the tripple shot seems a bit too harsh tho. Was missing one rune on the last boss but could not clearly see which one before I perished.
Could need some more tweaks and visual feedback (i.e. position of the player in the perish zone, better visualization of cleared runes).
You should add the fullscreen button for the web build. You do not have to build a new version, it is just a checkmark when you edit the game page on itch. You can still edit the page, you just can not upload new builds.