Very glad to see the art is your own, as La Creatura is positively disgusting, as disgusting as it is hyped to be, so I was praying for it to have the look you wanted for it.
The wheel being of your design makes the wheel gimmick quite manageable and fun, out of all the ones I've played with such gimmicks, this is the one that gave me less friction in how I want my experience to be.
But the boss designs were a little weird next to each other, and I couldn't truly get the setting from them. Ninja girl in particular really looks lost here. 2nd Phase of La Creatura is terrible since you can't aim up or down in the game. Even a 45 degree angle would be be enough for at least the spread shooter to be more reliable against it.