TLDR: My advice for anyone starting a new play through is to accept EVERYTHING. Saying NO doesn't unlock alternatives, you don't miss anything by saying YES.
------
Ok. I've just finished playing through the update on my two different play throughs and I've noticed some inconsistencies.
The two different play throughs diverged at the very important decision you make with Sandra in the Spa (trying to avoid spoilers).
The route where the MC declines her has some inconsistencies in this update. Mostly involving dialogue that references things that haven't happened on this route but did in the other.
Specifically, In the "Decline" route, Lucy is suddenly on her period and it's completely normal where previously she said that she stopped having them years ago and wasn't bothered about it. Only in the "Accept" route is there a conversation where she tells MC that they have started again.
Then in the morning of day 3, Lucy mentions watching Sandra and MC together the previous day, but that doesn't happen in the "Decline" route.
That's enough for now but that's only the first 3 days of the update.