Thanks :) The default key for changing the selected target is 'Tab'. I anticipated that people might run into this issue, so I made the loading screen basically be "Press 'Switch Target' to continue...' Perhaps I should've displayed it in game as well if players repeatedly try to heal / shield the boss.
And yeah, the combat is hard. This is probably equivalent to heroic difficulty in an MMO.
What are you systems specs? Would you be able to send a screenshot of the default purple mesh?
[edit] Checked out your game. Very cool :)