This shows potential for a good runner game. Having different environments for each run really adds to replayability.
I didn't find myself particularly motivated to avoid damaging pickups because healing pickups were abundant, and they were often right before holes, and jumping over them put me in more danger than simply collecting them. There's also a lot of unused space on the screen. You might consider adding some verticality to gameplay by making the player jump higher (either inherently or with powerups) to allow them to access platform pathways above ground level with other pickups and hazards.
Nevertheless, you're off to a good start.
Fine work, and good luck! :D