Yep, I saw that on stream just now. Without it though I did manage over 250 just now :D
Using enter to quickly refresh the board to look for molecules in high demand is also a pretty good strategy, since ammonia when it's in high demand is worth 60.
I haven't ever been able to get methane though, so maybe some feedback is to roll a die and with low probability, modify the board after generation to put hydrogens on all 4 sides of a given carbon?