Very interesting concept! We have seen deck building in shooters before, but the idea of picking up "Negative" modifiers instead of losing health is very new, and combined with the fact that the modifier might be together with the weapon you need, makes you judge if it's worth to take the negative hit or to keep rolling for a weaker weapon.
The starting pistol felt too weak and inaccurate, but other than that with some polish this is a really interesting idea with a lot of potential. Nice game!