Max points on Originality, makes me want to read a book about this or watch a movie.
The design is solid, so is the layout, and the adherence to theme is wrapped in there too. The ticking timer of the Madness getting slowly more and more powerful is amazing, I totally see that as a successful adherence to theme.
I would love a one-off campaign book/rule book with this setting and gameplay about delving into a dude’s mind to get what you need to save the world. Awesome.