I think the main concern for at-home printers would be “less full-page solid black backgrounds”. I wouldn’t necessarily change anything else like headers and tables.
But on the other hand, I have printed stuff with solid black backgrounds, and even though my ink cartridges hate me for it, DAMN does it come out looking delicious… 😂😭
I guess “low ink without sacrificing your design vision too much”?
As for spreads, there are 2 kinds, right?: true spreads that make your design intent shine as intended when viewed on screen (but which can also be achieved by turning on “facing pages” in your reader), and “booklet” printing spreads for saddle stitching, which are super helpful for at-home printers.
(I’ve personally invested in an app called “booklet creator” which transforms PDFs to duplex-ready spreads)
I’ve done a lot of thinking about this as well, for when I finally put up my own booklet, and I think the conclusion is: can’t hurt to have more formats, as long as generating them isn’t a time-sink per update…