I might not be the target audience with my smooth brain but the concept is really good. I went through the tutorial and was still kind of confused on completion. It might be silly to try and work on that if you are still figuring out mechanics though.
It felt like there was a lot of things to track and that they could have been introduced a bit better. For example when you mention in the tutorial certain icons, on screen you could darken the rest of the screen / highlight those areas.
I was guessing the loss condition was the brain % going to 0 and that the statements that were coming in the top right were countdown things to deal with by replying with cards. Not sure if that was skipped over in tutorial.
Best suggestion I have is to try and simplify / reduce the noise on screen so as a new player I'm not overwhelmed. Turning off the changing head and greying flavor text so as the player I know what I want to focus on. Making intractable elements highlighted either on mouse over or if you have a card selected to highlight areas they can be dragged too. Like how they handle cards in Cultist Simulator.
Actually looking at Cultist Simulator could be really useful if you haven't seen it before. It is a complex game but they do a lot to keep things manageable on screen so you know what is going on and what to track. I think the game could be really cool but your UI is stopping me from getting into it.