In some older threads it has been suggested that you can do this by typing "?exclude=tg.nameofthing" but I don't think I need to explain that if the only way to do something is to type obscure hard to remember text commands into a url and there's no button or other interface element that also does this then it is not really a feature and still needs to be added. Itchio already has so many good sorting tools... I get that you're a small team and have limited bandwidth for adding new features but why has more robust exclusive filtering still not been added after all this time? Especially when its absence is negatively affecting the experience of using the site in such a big way?
(it's certainly not just me, judging by all the similar request threads going back years)