This is fantastic - the skill tree is wide and varied, with a whole lot of very exciting powers, and makes really excellent use of the dice - you've mentioned elsewhere in the comments that your focus was on input rather than output randomness and this really comes through, with the skill tree containing many ways to use dice of all scores.
I loved the aspects that encouraged considering whether it was worth retaining die for subsequent turns: in one playthrough I ended up holding a pair of twos for multiple rounds in the hope I'd roll a third and unlock the opportunity for criticals, and in another I had to debate whether to it was worth spending my valuable pocket 6s or to retain them to keep a chance at criticals each turn. Decisions felt well balanced, and gave me plenty of room to adapt on the fly based on my rolls.
Unfortunately I wasn't able to finish the game as it'd crash after a few rounds on each playthrough - if it's any help, the output of the console is below:
Uncaught RuntimeError: null function or function signature mismatch at Build.wasm:0xbc98d2 at Build.wasm:0x237cef at Build.wasm:0xbc9c1e at Build.wasm:0x8921d at Build.wasm:0x360181 at Build.wasm:0x273c02 at Build.wasm:0x7eec2a at Build.wasm:0x3da6a at Build.wasm:0x7d393e at Build.wasm:0x578d7 at Build.wasm:0x6a5f3 at Build.wasm:0x815364 at invoke_viiii (Build.framework.js:3:351980) at Build.wasm:0x7518a8 at Build.wasm:0x5ee2e at Build.wasm:0x26c10e at Build.wasm:0x1bffc2 at Build.wasm:0x3ebb20 at Build.wasm:0x3ec62b at Build.wasm:0x7d191b at Build.wasm:0x7d4094 at Build.wasm:0xb58527 at Build.wasm:0x235644 at Build.wasm:0x8153c0 at invoke_iiii (Build.framework.js:3:351811) at Build.wasm:0x66209 at Build.wasm:0x672f76 at Build.wasm:0x4234c at Build.wasm:0x3391b6 at Build.wasm:0xaece81 at Build.wasm:0x4a3c59 at Build.wasm:0x894904 at Build.wasm:0x6072d0 at Build.wasm:0x607341 at Build.wasm:0x42a28c at Build.wasm:0x815342 at browserIterationFunc (Build.framework.js:3:203492) at callUserCallback (Build.framework.js:3:156817) at Object.runIter (Build.framework.js:3:158077) at Browser_mainLoop_runner (Build.framework.js:3:156352)