Ok, ok...
Can you clean the save/persistent folders?
You need to delete/move the following folders:
C:\Users\<USER>\AppData\Roaming\RenPy\LoSe_20_1-1512630773 C:\<THE_PATH_OF_THE_GAME>\Love & Sex Second Base\game\saves
Once the two folders are deleted/moved, launch the game.
Probably unrelated but..., the windows path is limited to 256 characters.
You can try to move the folder directly in the root folder of your hard drive.