Hi Andy! To be perfectly honest, while I personally find Twine to be more intuitive, using many images may require a lot of CSS and HTML knowledge. If you're comfortable with that, then it may also be intuitive for you. However, if aligning/positioning images is something you don't want to do, you may want to consider Visual Novelty or Renpy.
Between Renpy and Visual Novelty, I'd say VN may be more beginner-friendly, as it has a visual interface rather than Renpy's pure-code editor.
About images and Twine though: it really just depends on the complexity of what you want to do. If you're trying to make a VN-like game in Twine, it's completely possible, but you'll have to code the framework yourself, which may be more work. Does this help?