What a juicy entry! I love how you _feel_ every trash you clean up, it's super satisfying. I have two complaints though, the monochromatic style combined to the effects on Poison-man's attacks make the game really hard to read, and the white flash when you clean something becomes tiresome for the eyes after a while.
The upgrades are cool, you can see different paths through them (going faster or hiring more workers?), which makes me want to try different builds.
At some point I realized I couldn't lose, and that there was no real objective, and it kinda broke the game for me. Maybe a satisfaction meter that goes down the more trash there is and end the game when it reaches 0 could be a good incentive for players to play as well as they can?