I encountered the same issues. Nothing was being read aloud by my screen reader. In the first scene, I could not progress because sprinting was not working with my gamepad, but switching to the keyboard worked for me. Then it was unclear where to go in the second scene, but eventually moving forward enough you will hit your first cutscene. The game gets easier after that because it introduces the navigation mechanic. However, I still had difficulty at points understanding where to go with my ears alone.
The game is otherwise visually beautiful, with great voice acting, and a surprising number of accessibility options. It just needs slightly more polish for it to be fully playable. The team here should be very proud of this very nice submission nonetheless.