One recommendation: remove +XP upgrade, it's pretty useless. You would need above 20 levels to make it useful if each level required the same amount of XP (which is not the case). Your final level is not that far from the 20 mark at the end, so the +XP is rarely profitable. In other survivors like, +XP is useful because one game last long, so the bonus XP is profitable, plus often you gain more stat with each level, so even you don't get enough the be profitable level-wise, it's profitable for the stats on level-up.
For those having difficulty: focus everything on + attack and + attack speed (with seed, jack and D-bug to pick as soon as they appear).
Only pick sub weapon if no attack option (except maid (half your DMG) and mermaid (knockback) that you can pick if you are confortable with your current DMG) (the subweapons don't get more powerful so they are pretty useless at the end)
Make sure that you pick 2 times +speed (+ the +speed per kill) near the end to avoid more easily the attacks of the final boss, and pick 1 regen + 1 defense if you want safety.
Pick 2-3 +pickup range when you are confortable.
Only pick +XP if you only have defense option and you already have your safety margin