Awesome game. Here's some feedback:
I think the way in which the control modes work is not optimal sometimes, and you need to click and click ad infinitum. There should be an 'end turn' only button for when you do not wish to use any cards in your turn.
The 'boss' in the castle run just played a card that makes it lose 1 life when at 1 life left. Maybe add some checks to pc decision making for better difficulty.
The card crafting is a great feature.