Hey DeadStack. The game has been designed to use the mouse, with tooltips on everything, icons to click (or use hotkey), movement with WASD and some other things. I have some tasks on the list that will allow targeting abilities without a mouse and might as well add a posibility to pickup with just keyboard, however this kind of playstyle will always be subpar to the mouse + keyboard. I play on laptop sometimes so I understand it could be beneficial to play the game without a touchpad.
Autopickup unfortunately doesn't fit the game, there are a number of limitations to this feature like moving the time forward which could be deadly and frustrating during combat, weight and limited backpack slots.