I have Windows 7, 500-ish G of disk space, I don't know what my RAM is, I'm about to go to work but I'll look it up when I get home. So far it's the only game on itch I haven't been able to run so I wasn't sure if it was something I was doing wrong or if it's some program my computer doesn't have.
I highly suspect it might be your Operating System. Renpy is known to not work 100% on that. Renpy 8 uses Python 3 for example and that just straight up doesn't work at all on Win7. Although. Minotaur Hotel's latest build was made with Renpy 7, so it might not be the reason.
Have you tried running it as admin, by the way?