Well major bug in the new version. It literally won't let me save.
While running game code:
File "renpy/common/00action_file.rpy", line 383, in __call__
renpy.save(fn, extra_info=save_name)
Exception: Not saved - no valid save locations.
I was able to save when I tested it out, so it might be something on your end.
From looking it up, it seems it might be a permissions issue or an issue when trying to open it on the itch.io desktop app (mac) (in that situation opening the game directly from the desktop worked). I don't know if this will help, but I can't find anymore solutions at the moment