So you tried running MewnBase.exe from both the mewnbase-win.zip download, as well as the mewnbase-win32.zip version, on a Windows 10 machine and neither of them would start for you? Do you know what sort of video card your machine has in it?
If you previously tried downloading it via the itch desktop app - try uninstalling and reinstalling the latest win32 version. (Which sometimes fixes a issue with the game sometimes not being able to launch).