Heyo! Thanks for the comments <3
My house has a "problem" with overcooked style games and ended up talking about what mouse-interaction would be like over the course of the jam. Our consensus is that it'd be interesting but dramatically change the "feel." We find that a large part of the challenge for these is the frantic pathing and trying to target correctly under duress. Switching to (presumably) an efficient path from point a to b removes that bit of the challenge somewhat and so you end up relying increasingly on the question of action order efficiency. In effect I think you'd see a slightly lower skill floor (imo good) but also a dramatically lower skill ceiling (imo bad) so existing mechanics would have to change in some other way.
Not sure how but I'm excited to see if somebody does take that route.