Oof, yeah, RNG can be a real pain. One easy way to avoid it is to use the All In ability where you are guaranteed to take a hit first but you are also guaranteed a hit yourself with 1.5x damage. You can build for this by focusing on STR and CON for damage resist and with a bit of luck, getting the Cultist Cloak item for more damage resist. A tiny bit of INT also goes a long way with allowing you to heal yourself more. Hope this helps!
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I might give that a try. Regardless, it was a lot of fun and it might be on me too for spreading my points across three skills instead of focusing on anything. Just overall got the feel that enemies had a tad too much health and that both them and I were missing a lot. That may be an early game problem more so though