It looks as though the escape key doesn't work in menus, owing to the fact there is no way out of the options or learn sounds menu. With there being no exit option as well, the only option here seems to be to enable talkback and access quick-settings or notifications to get out of the game
Additionally, if you do not wait to disable Talkback until the please make sure your screen reader is disabled message finishes speaking, the game doesn't take it as a cue to initialize.