It would be nice if there was a lineart clean up feature from a 2D sketch.
You could use something similar to aseprite smart trace algorithm to create cleaned up pixel art strokes.
It could be something like using some kind of detect edge algorithm and then simply collapse the width of the strokes until there's 1 pixel stroke. (basically use the high res picture to create vector lines used to redraw the smaller resolution picture using a single 1 px stroke).