At present, the game stops if the player reaches one of the Victory conditions.  Consider giving players the option to continue playing until they've achieved ALL of the Victory conditions.

Having played Cardalaxy a couple dozen times, now, I've noticed something about the current Wellness mechanic.

Once the player has reached the first Wellness milestone, the Wellness decay mechanic pressures the player into investing heavily into Wellness to stay ahead of the decay.  Unlocking Health Tracking Centers and/or Modular Farms becomes a major survival priority for the player, as a result.  However, once either of those are unlocked, it becomes much easier to overshoot the Wellness decay and jump straight to victory.

I therefore suggest two changes:

1) Currently, the rate of decay is a function of the highest Wellness the player has ever reached.  Change this to instead be a function of the player's current Wellness; as Wellness drops, Wellness decay should also drop.

2A) Double the Wellness amounts required for all milestones OR...

2B) ...add more Wellness milestones such that Victory is still the last milestone, but requires 100 Wellness.

Increase the delay between a boss being defeated and the next one showing up.  Or, perhaps, have an (early-game-unlockable) toggle for aggressive/normal/defensive that makes all ships show up immediately/after one turn/after two turns.

"Can't replace a building with the same building."

While this makes sense in the general case, Space Mines need to be refreshed and thus should be exempt from this rule.

Either that, or just rework Space Mines completely.  The mechanic from your older game, "Planet Crafter" will suffice: 1 Combat plus 1 Combat for each other Space Mine played on the same turn.

First Wellness milestone sometimes presents the following two options:

"Cooperative Endeavors": Gains 3 Science when completing a missions and gain 3 Exploration when completing a Technology.

"Surplus": Gain 3 random points each turn.

Completing missions and/or technologies doesn't happen every turn.  The player ALWAYS gets more points in the long run by choosing "Surplus".  I suggest increasing "Cooperative Endeavors" to at least 8.

For a deck-building adjacent game (deck-management?) I feel like I have very little control over what I'm dealt, and have no way to line things up. I'm working with what is given to me, and sometimes that leaves me with really good or really bad turns.

Once you've got your victory condition in mind, the other symbols don't do much. If I'm going a science route, you want just barely enough combat and health, and exploration be damned. 

If I'm going for a science victory, I don't feel like I can splurge and go for the cool things on the side. Any decision that isn't going straight to the top of the track feels wrong.

Combat units come quickly. Defeating them feels less rewarding than just pinging them so they won't bother you.

I'd like some stats/charts regarding my deck and it's contents. Just some rough things to look over more quickly when making decisions. How many open building spots do I have, what's my average combat per planet, what's the total population of my empire, etc. 

My first set of suggestions since Version 0.4 went live:

1) "Space Mines", "Gives: Gives 5 Combat -1 per turn when played."

This is useful over the span of 5 turns for a total of 15 Combat, which is an average of 3 Combat per turn when played.  Tier 2 buildings that do NOT require a strategic resource give a guaranteed 3 points per turn when played and don't need to be refreshed.  This makes Space Mines underpowered compared to the Tier 2 baseline.

I suggest one of the following:

A) "Gives 9 Combat -1 per turn when played" <-- Average of 5 Combat per turn.

B) "Gives 5 Combat." <-- This brings Space Mines up to the power level of Modular Farms and Orbital Telescopes, which also require Strategic Resources.

C) "Gives 1 Combat +1 Combat per other Space Mine played this turn." <-- I think you had this right the first time in your earlier game, "Planet Crafter".  Just borrow that mechanic.  (As an aside, "Planet Crafter" has had a couple of unfixed bugs for the past few years.)

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2) "Arcology", "Gives: Gives 3 Random Points to all active crises when played."

This is comparable to the Tier 2 building "Crisis Response Center" (if I remember the name correctly; I don't have the building in front of me right now) which requires a Water strategic resource to build.  "Arcology" is supposed to be a Wonder; increase the build cost to 12 and have it give 8 Random Points to all active crises when played.  (This might need further adjustment once Tier 3 buildings are introduced, but until then, this suggestion should suffice.)

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3) The animation for shooting enemies with the laser is a bit slow, especially if I'm shooting the Mothership 20 times all at once.  I suggest cutting the animation time per shot in half.

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4) Regarding this selection (and similar selections): make the box bigger and put the planet inside the box.  As it is now, the colored outline draws the player's eyes to the contents of the box, making it less likely that the player will look outside that box.