I really appreciate your vision here and what you've got planned sounds exciting, I love stacking status effects to compound upon someone's helplessness. But do the graphics need to be so small? The enemy sprites are miniscule and the character portraits are crowded together so tightly they only use about 10% of the screen's real estate! It makes it really hard to appreciate the visuals
No, F4 does not fix it. It just fullscreens the window but doesn't change the resolution of the actual game graphics. Here: a screenshot of what I'm talking about and as a point of comparison, a screenshot of the same size of Mira Co. Rescue. Not only are things super tiny, but there's so much screen space not being used! You could easily space out the portraits a bit more to give them more breathing room