names aren’t the same if you changed the seed, do you mean the best friend?
It basically depends on their part in the story. Romance isn't possible (yet) with the quarterback, but you can have a D/s relationship with the RM/RMP since it's in their storyline. Some special NPCs (the rich kid, QuickieBurger owner, etc.), even if they're single, also aren't romanceable to male protagonists because they're straight.