Sweet! Excited to see it.
You could probably use the raycast from camera trick to make mouseclicks work across the screen. Have planets orbit or something with monitors on each that people have to click :)
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Those are good ideas. Thank you very much for them! I've done a game before where a sprite always follows your mouse. It was a block breaker game where the paddle followed the horizontal movements of your mouse. It's not on here, however ^^' Making the mouse clicks work no matter where your mouse is is easy enough with a simple GetKeyDown(KeyCode.Mouse0)/GetKeyDown(KeyCode.Mouse1) and such which monitor the clicks and such. If you meant something else, sorry, i didn't understand what you meant.