I like it overall. Quite similiar to cataclysm setting wise.
Only thing that really bothered me was the "sensitivity" of repeating key presses. I wanted to wait a turn but I waited several because I didn't release the key fast enough. Disabling mouse hold move helped, but now walking long distances is unpleasant. Good compromise would be for keys to start repeating only if you hold it for more than a second. Cataclysm does that I think. Also, I couldn't move with containers opened. They always closed when I moved.
Other than that, nothing struck me as bad or wrong. Mutations were leaning a little too much on the negative side, some classes don't seem that useful to me and equipment seemed a little too rare, but that's about it. I quite like it. Did several runs and got the swamps with the wisps.