Hi there
These themes are all in relation to mental health after COVID.
During the start of the COVID-19 pandemic, mental health conversations grew significantly within communities and amongst peers. It almost acted as a catalyst for further mental health discussion. It was throughout that time that many people felt more able to share their stories and experiences. That doesn't mean your game must explicitly be around COVID-19, but instead incorporates themes in which were felt during that time in relation to our mental health.
Essentially, they are left to interpretation to inspire creativity within your own theme for the game; you don't need to pick one or all or any, if none are calling to you, but the main theme of the game should be focused around mental health.
Hope this helps!