Maybe it's just me, but I'd like to see a point where, if you survive long enough, certain checks are automatic successes. Especially with the lab once you've made something enough times. As for more general checks, have the stat measured against its fatigue to balance out success vs failure. Some checks, of course, should always have a chance to fail (like against the bandits).
That would probably mess with the balance a bit. But the RNG of what you encounter can already screw you over pretty quick. That's just how all Rogue games are.