This is likely an issue with your file explorer, you might have the game's folder or the folder it's in set to read only. I'd bet there's solutions online for this that apply to all RPGMaker games, see if Google tells you anything.
Zenthicks
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This could happen if you went through a section that disables the menu and somehow missed the trigger to enable it again. This is meant to be impossible, I'll look through that section to see if I missed something. If this happens you can fix it by opening the sidequests board since it runs the disable/enable menu command.