For quests that I can't do or don't want to do, assignment quest being a good example, I take the quest and then forfeit it. This removes the quest so it isn't still around the next week..
I have done a Ancient Jungle quest before Day 21, I ran away a lot. Took two excursions to complete. I also do lot of dungeons (not nearly as many as some) thus I have some looted gear and lots of classes. The new random buffs on dungeon opponents can make some fights very difficult. Bard and shaman classes have become more useful.