Yeah, Synergism is mentioned on the description page.
If there is an issue with high numbers in Unity, couldn't you just introduce a new currency where 10^303 = 1. And every time you hit 10^303 you have another new currency. Like having Copper, Silver, Gold, Platinum in old school D&D games, you could have neo, heavenly and godlike (or whatever) as incrementally higher versions of the same currencies.
So something could cost 1 neo Karma and 3.6e31 Karma, for example.