I just managed to get this running fwiw. My setup is Ubuntu 22.04 and I was trying to run the game through the itch.io desktop app. It’s worth looking through the error logs to make sure you’re facing the same problem and be comfortable with using sudo on the command line, but including it here in case it helps someone.
The first error was around around a missing libcrypto.so.1.0.0, part of libssl. I managed to install it using these instructions. Basically the version of libcrypto the GameMaker runner requires is too old so you need to add another repository to be able to install it.
I then got a different error about it not being able to find the game.unx file. In the file manager I only add Mable_PC and Mable_PC.zip - I just unzipped the latter, which contained an assets folder and in it was the game.unx file. After that I could start the game.
Hope this helps someone - I’m looking forward to actually trying the game!